Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine

被引：0

作者：

Lei, Huajun ^{[1
]}

Wang, Min ^{[1
]}

Han, Jiaqian ^{[1
]}

Lan, Zhou ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

PROCEEDINGS OF THE 2016 7TH INTERNATIONAL CONFERENCE ON EDUCATION, MANAGEMENT, COMPUTER AND MEDICINE (EMCM 2016) | 2017年 / 59卷

关键词：

Thieno [2,3-d] pyrimidine; Phosphoinositide; 3-kinase; Synthesis; INHIBITOR; POTENT; CANCER;

D O I：

暂无

中图分类号：

F [经济];

学科分类号：

02 ;

摘要：

Thieno[2, 3-d]pyrimidine is a key intermediate in many biologically active compounds such as GDC-0941 and BKM 120. In this work, a rapid synthetic method for compound (4) was established. The compound (4) was synthesized from the commercially available methyl 2-aminothiophene-3-carboxylate and formimidamide through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by MS and H-1 NMR. Furthermore, the total yield of the three steps was 54%.

引用

页码：595 / 598

页数：4

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