Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma

被引：11
|
作者：
Zivicova, Veronika [1 ,2 ,3 ]
Gal, Peter [4 ,5 ]
Mifkova, Alzbeta [1 ,2 ,3 ]
Novak, Stepan [1 ,2 ,3 ]
Kaltner, Herbert [6 ]
Kolar, Michal [7 ]
Strnad, Hynek [7 ]
Sachova, Jana [7 ]
Hradilova, Miluse [7 ]
Chovanec, Martin [8 ]
Gabius, Hans-Joachim [6 ]
Smetana, Karel, Jr. [1 ,9 ]
Fik, Zdenek [1 ,2 ,3 ]
机构：
[1] Charles Univ Prague, Inst Anat, Fac Med 1, Prague, Czech Republic
[2] Charles Univ Prague, Fac Med 1, Dept Otorhinolaryngol Head & Neck Surg, V Uvalu 84, Prague 15006 5, Czech Republic
[3] Univ Hosp Motol, V Uvalu 84, Prague 15006 5, Czech Republic
[4] East Slovak Inst Cardiovasc Dis Inc, Dept Biomed Res, Ondavska 8, Kosice 04011, Slovakia
[5] Pavol Jozef Safarik Univ Kosice, Fac Med, Dept Pharmacol, Kosice, Slovakia
[6] Ludwig Maximilians Univ Munchen, Fac Vet Med, Inst Physiol Chem, Munich, Germany
[7] Acad Sci Czech Republ, Inst Mol Genet, Lab Genom & Bioinformat, Prague, Czech Republic
[8] Charles Univ Prague, Univ Hosp Kralovske Vinohrady, Dept Otorhinolaryngol & Head & Neck Surg, Fac Med 3, Prague, Czech Republic
[9] Charles Univ Prague, BIOCEV, Fac Med 1, Vestec, Czech Republic
来源：
ANTICANCER RESEARCH | 2018年 / 38卷 / 03期
关键词：
Extracellular matrix; fibronectin; galectin; tenascin; tumor; stroma; ADHESION/GROWTH-REGULATORY GALECTINS; MOLECULE B-CAM; STROMAL FIBROBLASTS; COLON-CANCER; NETWORK; LEPTIN; GROWTH; ACTIVATION; PROGNOSIS; LECTINS;
D O I：
10.21873/anticanres.12350
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Having previously initiated genome-wide expression profiling in head and neck squamous cell carcinoma (HNSCC) for regions of the tumor, the margin of surgical resecate (MSR) and normal mucosa (NM), we here proceed with respective analysis of cases after stratification according to the expression status of tenascin (Ten). Materials and Methods: Tissue specimens of each anatomical site were analyzed by immunofluorescent detection of Ten, fibronectin (Fn) and galectin-1 (Gal-1) as well as by microarrays.
引用
收藏
页码：1279 / 1290
页数：12
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