D-Optimal Designs for Covariate Models

The problem of finding D-optimal designs in the presence of a number of covariates has been considered in the one-way set-up. This is an extension of Dey and Mukerjee (2006) in the sense that for fixed replication numbers of each treatment, an alternative upper bound to the determinant of the information matrix has been found through completely symmetric C-matrices for the regression coefficients; this upper bound includes the upper bound given in Dey and Mukerjee (2006) obtained through diagonal C-matrices. Because of the fact that a smaller class of C-matrices was used at the intermediate stage where the replication numbers were fixed, ultimately some optimal designs remained unidentified there. These designs have been identified here and thereby the conjecture made in Dey and Mukerjee (2006) has been settled.