Increased serum levels of CD95 in Alzheimer's disease

被引：14
|
作者：
Richartz, E
Noda, S
Schott, K
Günthner, A
Lewczuk, P
Bartels, M
机构：
[1] Univ Tubingen, Dept Psychiat & Psychotherapy, D-72976 Tubingen, Germany
[2] Univ Gottingen, Neurochem Lab, D-3400 Gottingen, Germany
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2002年 / 13卷 / 03期
关键词：
Alzheimer's disease; apoptosis; CD95; Fas; Apo-1; neurodegenerative disorders; peripheral markers;
D O I：
10.1159/000048650
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
There is growing evidence for a role of apoptosis in Alzheimer's disease (AD). Recent findings suggest an increased susceptibility of lymphocytes to apoptosis in AD. To prove the hypothesis of systemic alterations in the apoptotic balance in AD, serum and cerebrospinal fluid levels of soluble CD95, which is known to mediate apoptosis, were measured. In the serum, AD patients exhibited significantly higher levels of CD95 than the controls (p = 0.017), suggesting an involvement of peripheral markers in AD. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码：178 / 182
页数：5
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