Application of sharpless asymmetric dihydroxylation to synthesis of chiral β-amino alcohols

被引：0

作者：

Liu, WM ^{[1
]}

Liu, XY ^{[1
]}

Song, RJ ^{[1
]}

Zhang, SY ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Dept Chem, Xian 710032, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 26卷 / 03期

关键词：

asymmetric dihydroxylation; asymmetric synthesis; chiral vicinal diol; chiral beta-azido alcohol; chiral beta-amino alcohol;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of enantiopure beta-amino alcohols were synthesized from the corresponding diols produced by Sharpless asymmetric dihydroxylation, cyclization of diols, azide opening of epoxides, and catalytic hydrogenation of the resulting azido alcohols. Factors to affect the azide opening of the epoxides were examined. Overall yields from epoxides to amino alcohols were 89%similar to 94%, while enantiomeric excess values of beta-azido alcohols and beta-amino alcohols were up to 90%similar to 99%.

引用

页码：341 / 345

页数：5

共 17 条

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