Efficient one-pot synthesis of novel and diverse tetrahydroquinolines bearing pyranopyrazoles using organocatalyzed domino Knoevenagel/hetero Diels-Alder reactions

A new synthetic route to biologically interesting diverse tetrahydroquinolines bearing pyranopyrazoles was developed by reacting pyrazolones and ,-dialkylated aminobenzaldehydes in the presence of EDDA. The key strategy underlying the methodology used was the domino Knoevenagel/hetero Diels-Alder reaction. This synthetic method provides a variety of novel tetrahydroquinolines in good yields.