Gold/BrOnsted Acid Relay Catalysis for Enantioselective Construction of Spirocyclic Diketones

被引：53
|
作者：
Qian, Deyun [1 ]
Zhang, Junliang [1 ]
机构：
[1] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 22期
关键词：
asymmetric catalysis; gold; quaternary center; relay catalysis; spirocycles; STEREOSELECTIVE CONSTRUCTION; GOLD; METAL; FLUORINE; LIGANDS;
D O I：
10.1002/chem.201301208
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Golden opportunities: A redox-, atom-, and step-economical asymmetric cascade reaction for the synthesis of chiral spirocyclic architectures with two contiguous stereocenters in high yields and excellent enantioselectivities by using a gold/chiral Brønsted acid relay catalysis system is described (see scheme). The results suggest that the chiral Brønsted acid rather than the chiral gold phosphate complex serves as the real catalyst of the enantiodetermining step. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：6984 / 6988
页数：5
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