Back to the future: Why we need enzymology to build a synthetic metabolism of the future

被引:18
|
作者
Erb, Tobias J. [1 ,2 ]
机构
[1] Max Planck Inst Terr Microbiol, Dept Biochem & Synthet Metab, Karl von Frisch Str 10, D-35043 Marburg, Germany
[2] LOEWE Ctr Synthet Microbiol SYNMIKRO, Marburg, Germany
来源
基金
欧洲研究理事会;
关键词
enzymes; in vitro biochemistry; metabolic engineering; synthetic biology; CROTONYL-COA CARBOXYLASE/REDUCTASE; RUBISCO-LIKE PROTEIN; DESIGN; ENZYME; EVOLUTION; ASSIMILATION; PATHWAYS; FIXATION; HISTORY; ENABLES;
D O I
10.3762/bjoc.15.49
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Biology is turning from an analytical into a synthetic discipline. This is especially apparent in the field of metabolic engineering, where the concept of synthetic metabolism has been recently developed. Compared to classical metabolic engineering efforts, synthetic metabolism aims at creating novel metabolic networks in a rational fashion from bottom-up. However, while the theoretical design of synthetic metabolic networks has made tremendous progress, the actual realization of such synthetic pathways is still lacking behind. This is mostly because of our limitations in enzyme discovery and engineering to provide the parts required to build synthetic metabolism. Here I discuss the current challenges and limitations in synthetic metabolic engineering and elucidate how modern day enzymology can help to build a synthetic metabolism of the future.
引用
收藏
页码:551 / 557
页数:7
相关论文
共 50 条