Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress☆☆☆☆☆☆☆☆

被引：6
|
作者：
Wang, Shaoxian [1 ,2 ]
Chen, Jiaxu [1 ]
Yue, Guangxin [3 ]
Bai, Minghua [1 ]
Kou, Meijing [1 ]
Jin, Zhongye [1 ]
机构：
[1] Beijing Univ Chinese Med, Sch Preclin Med, Beijing 100029, Peoples R China
[2] Hebei Med Univ, Tradit Chinese Med Coll, Shijiazhuang 050000, Hebei Province, Peoples R China
[3] China Acad Chinese Med Sci, Inst Basic Theory Chinese Med, Beijing 100700, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 18期
基金：
中国国家自然科学基金;
关键词：
neural regeneration; chronic immobilization stress; hypothalamus; arcuate nucleus; double immunofluorescence; neuropeptide Y; leptin receptor; feeding center; body weight; grants-supported paper; neuroregeneration; FOOD-INTAKE; ARCUATE NUCLEUS; MESSENGER-RNA; BODY-WEIGHT; STRESS; BRAIN; PATHWAYS; NEURONS; OBESITY;
D O I：
10.3969/j.issn.1673-5374.2013.18.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this study, Sprague-Dawley rats were immobilized to a frame for 3 hours a day for 21 days to establish a model of chronic immobilization stress. The body weight and food intake of rats subjected to chronic immobilization stress were significantly decreased compared with the control group. Dual-labeling immunofluorescence revealed that the expression of leptin receptor and the co-localization coeffient in these leptic receptor neurons in the arcuate nucleus of the hypothalamus were both upregulated, while the number of neuropeptide Y neurons was decreased. Chronic immobilization stress induced high expression of leptin receptor in the arcuate nucleus and suppressed the synthesis and secretion of neuropeptide Y, thereby disrupting the pathways in the arcuate nucleus that regulate feeding behavior, resulting in diminished food intake and reduced body weight.
引用
收藏
页码：1721 / 1726
页数：6
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