HEPARAN SULFATE SIDE CHAINS ARE ESSENTIAL FOR THE MODULATION OF IL-1 SIGNALS BY SYNDECAN-4 IN RA SYNOVIAL FIBROBLASTS

被引:0
|
作者
Godmann, Lars [1 ]
Stratis, Athanasios [1 ]
Cromme, Christoph [1 ]
Echtermeyer, Frank [2 ]
Pap, Thomas [1 ]
Bertrand, Jessica [1 ,3 ]
机构
[1] Univ Munster, Inst Expt Musculoskeletal Med, Munster, Germany
[2] Hannover Med Sch, Dept Anaesthesiol & Intens Care, Devis Expt Anaesthesiol, Hannover, Germany
[3] Queen Mary Univ London, William Harvey Res Inst, London, England
关键词
D O I
10.1136/annrheumdis-2011-201238.16
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:A79 / A79
页数:1
相关论文
共 40 条
  • [1] Syndecan-4 is able to modulate il-1 signals by its heparan sulphate side chains in ra synovial fibroblasts
    Godmann, L.
    Stratis, A.
    Cromme, C.
    Echtermeyer, F.
    Pap, T.
    Bertrand, J.
    INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2013, 94 (01) : A21 - A21
  • [2] IL-1 DEPENDENT SYNDECAN-4 SIGNAL TRANSDUCTION IS MEDIATED BY ITS HEPARAN SULFATE SIDE CHAINS IN RA SYNOVIAL FIBROBLASTS
    Godmann, L.
    Stratis, A.
    Cromme, C.
    Echtermeyer, E. Frank
    Pap, T.
    Bertrand, J.
    ANNALS OF THE RHEUMATIC DISEASES, 2013, 71 : 324 - 324
  • [3] Modulation of microvascular signaling by heparan sulfate matrix: Studies in syndecan-4 transgenic mice
    Li, JA
    Parovian, C
    Li, JY
    Hampton, TG
    Metais, C
    Tkachenko, E
    Sellke, FW
    Simons, M
    MICROVASCULAR RESEARCH, 2002, 64 (01) : 38 - 46
  • [4] Syndecan-4 is regulated by IL-1β in β-cells and human islets
    Brioudes, Estelle
    Alibashe-Ahmed, Mohamed
    Lavallard, Vanessa
    Berney, Thierry
    Bosco, Domenico
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2020, 510
  • [5] Multiple heparan sulfate chains are essential for optimal syndecan-1 function
    Langford, JK
    Cao, D
    Sanderson, RD
    MOLECULAR BIOLOGY OF THE CELL, 1997, 8 : 2287 - 2287
  • [6] The interaction of proteogylcans with Syndecan-4 is essential for the attachment of rheumatoid arthritis synovial fibroblasts to articular cartilage in vitro and in vivo
    Korb, Adelheid
    Niederreiter, Birgit
    Neugebauer, Katja
    Echtermeyer, Frank
    Dreier, Rita
    Pavenstaedt, Hermann
    Pap, Thomas
    Smolen, Josef
    Redlich, Kurt
    ARTHRITIS AND RHEUMATISM, 2008, 58 (09): : S295 - S295
  • [7] Production of intracellular IL-1α, IL-1β, and IL-1Ra isoforms by activated human dermal and synovial fibroblasts -: Phenotypic differences between human dermal and synovial fibroblasts
    Maret, M
    Chicheportiche, R
    Dayer, JM
    Gabay, C
    CYTOKINE, 2004, 25 (05) : 193 - 203
  • [8] SYNDECAN-4 CONTROLS INTERLEUKIN (IL)-1 RECEPTOR TRAFFICKING AND IL-1 SIGNALLING IN CHRONIC DESTRUCTIVE ARTHRITIS
    Godmann, L.
    Koenig, U.
    Stratis, A.
    Cromme, C.
    Neugebauer, K.
    Herzog, C.
    Korb-Pap, A.
    Niederreiter, B.
    Dankbar, B.
    Redlich, K.
    Echtermeyer, F.
    Pap, T.
    Bertrand, J.
    ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : A45 - A46
  • [9] Modulation of microvascular signaling by heparan sulfate matrix: Studies in syndecan-4 transgenic mice (vol 64, pg 38, 2002)
    Li, J
    Partovian, C
    Li, JY
    Hampton, TG
    Metais, C
    Tkachenko, E
    Sellke, FW
    Simons, M
    MICROVASCULAR RESEARCH, 2002, 64 (03) : 497 - 497
  • [10] THE SYNTHESIS OF IL-1 RECEPTOR ANTAGONIST (IL-1RA) BY SYNOVIAL FIBROBLASTS IS MARKEDLY INCREASED BY THE CYTOKINES TNF-ALPHA AND IL-1
    MARTELPELLETIER, J
    MCCOLLUM, R
    PELLETIER, JP
    BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1175 (03) : 302 - 305