cAMP and in vitro inotropic actions of secretin and VIP in rat papillary muscle

被引：4
|
作者：
Rice, PJ [1 ]
Lindsay, GW [1 ]
Began, CR [1 ]
Hancock, JC [1 ]
机构：
[1] E Tennessee State Univ, Dept Pharmacol, Johnson City, TN 37614 USA
来源：
PEPTIDES | 1999年 / 20卷 / 04期
关键词：
vasoactive intestinal peptide; secretin; isoproterenol; papillary muscle; inotropic responses; cAMP; adenylate cyclase; rat;
D O I：
10.1016/S0196-9781(99)00035-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Secretin and VIP stimulate cardiac adenylyl cyclase activity and exert a positive inotropic action in several mammalian species. This study examined positive inotropic activity and cAMP levels in rat papillary muscle. Isoproterenol and secretin increased contractions by 150 +/- 31% and 129 +/- 27%, respectively. VIP increased contraction by 30 +/- 21% only at 10 mu M. Isoproterenol significantly increased cAMP levels by 82%, whereas increases by secretin (58%) and VIP (56%) were not significant. These results are consistent with reports that secretin and VIP stimulate cardiac adenylyl cyclase in the rat, but suggest that cAMP tissue levels cannot totally explain the positive inotropic responses to secretin and VIP. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：519 / 522
页数：4
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