CCR5 deficiency attenuates obesity-induced insulin resistance through M2 dominant shift in adipose tissue macrophage

被引:0
|
作者
Ota, T. [1 ]
Sawamoto, K. [1 ]
Kitade, H.
Yamamoto, Y. [1 ]
Inoue, H.
Takamura, T.
Yamamoto, H.
Mukaida, N. [2 ]
Kaneko, S.
机构
[1] Kanazawa Univ, Frontier Sci Org, Kanazawa, Ishikawa 9201192, Japan
[2] Kanazawa Univ, Canc Res Inst, Kanazawa, Ishikawa 9201192, Japan
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
170
引用
收藏
页码:S77 / S78
页数:2
相关论文
共 50 条
  • [1] CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status
    Kitade, Hironori
    Sawamoto, Kazuki
    Nagashimada, Mayumi
    Inoue, Hiroshi
    Yamamoto, Yasuhiko
    Sai, Yoshimichi
    Takamura, Toshinari
    Yamamoto, Hiroshi
    Miyamoto, Ken-ichi
    Ginsberg, Henry N.
    Mukaida, Naofumi
    Kaneko, Shuichi
    Ota, Tsuguhito
    DIABETES, 2012, 61 (07) : 1680 - 1690
  • [2] Linagliptin-mediated DPP-4 Inhibition Attenuates Obesity-induced Insulin Resistance through an M2-dominant Shift in Adipose Tissue Macrophage
    Ota, Tsuguhito
    Fen Zhuge
    Ni, Yinhua
    Xu, Liang
    Nagashimada, Mayumi
    Nagata, Naoto
    Kaneko, Shuichi
    DIABETES, 2015, 64 : A479 - A479
  • [3] Dual CCR2/5 Antagonist Attenuates Obesity-Induced Insulin Resistance by Regulating Macrophage Recruitment and M1/M2 Status
    Huh, Ji Hye
    Kim, Hong Min
    Lee, Eun Soo
    Kwon, Mi Hye
    Lee, Bo Ra
    Ko, Hyun-Jeong
    Chung, Choon Hee
    OBESITY, 2018, 26 (02) : 378 - 386
  • [4] CCR5 promotes adipose tissue inflammation and insulin resistance in obesity
    Ota, T.
    Kitade, H.
    Sawamoto, K.
    Inoue, H.
    Kaneko, S.
    DIABETOLOGIA, 2010, 53 : S89 - S89
  • [5] Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
    Kyung Cheul Shin
    Injae Hwang
    Sung Sik Choe
    Jeu Park
    Yul Ji
    Jong In Kim
    Gha Young Lee
    Sung Hee Choi
    Jianhong Ching
    Jean-Paul Kovalik
    Jae Bum Kim
    Nature Communications, 8
  • [6] Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle
    Lee, Chi Ho
    Lam, Karen S. L.
    JOURNAL OF DIABETES INVESTIGATION, 2019, 10 (01): : 29 - 31
  • [7] Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
    Shin, Kyung Cheul
    Hwang, Injae
    Choe, Sung Sik
    Park, Jeu
    Ji, Yul
    Kim, Jong In
    Lee, Gha Young
    Choi, Sung Hee
    Ching, Jianhong
    Kovalik, Jean-Paul
    Kim, Jae Bum
    NATURE COMMUNICATIONS, 2017, 8
  • [8] Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
    Nomiyama, Takashi
    Perez-Tilve, Diego
    Ogawa, Daisuke
    Gizard, Florence
    Zhao, Yue
    Heywood, Elizabeth B.
    Jones, Karrie L.
    Kawamori, Ryuzo
    Cassis, Lisa A.
    Tschoep, Matthias H.
    Bruemmer, Dennis
    JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (10): : 2877 - 2888
  • [9] SCD1 deficiency prevents obesity-induced macrophage recruitment into white adipose tissue and improves the associated adipose insulin resistance
    Liu, Xueqing
    Flowers, Matthew
    Miyazaki, Makoto
    Chu, Kiki
    Ntambi, James
    FASEB JOURNAL, 2007, 21 (05): : A295 - A295
  • [10] CCR5 A novel player in the adipose tissue inflammation and insulin resistance?
    Ota, Tsuguhito
    ADIPOCYTE, 2013, 2 (02) : 99 - 103