Imaging Radiotherapy-Induced Apoptosis

被引：20

作者：

Haimovitz-Friedman, Adriana ^{[1
]}

Yang, Tzu-I Jonathan ^{[2
]}

Thin, Tin Htwe ^{[1
]}

Verheij, Marcel ^{[3
,4
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10065 USA

[2] Yale Univ, Sch Med, New Haven, CT USA

[3] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiat Oncol, NL-1066 CX Amsterdam, NH, Netherlands

[4] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Expt Therapy, NL-1066 CX Amsterdam, NH, Netherlands

来源：

RADIATION RESEARCH | 2012年 / 177卷 / 04期

关键词：

RADIATION-INDUCED APOPTOSIS; ANNEXIN-V SCINTIGRAPHY; PROGRAMMED CELL-DEATH; APO-1/FAS RECEPTOR/LIGAND SYSTEM; FLOW-CYTOMETRIC DETECTION; DIFFUSION-WEIGHTED MRI; DRUG-INDUCED APOPTOSIS; TUMOR-SUPPRESSOR P53; IN-VIVO DETECTION; MULTIDRUG-RESISTANCE;

D O I：

10.1667/RR2576.1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prediction of response to therapy has been identified as an important tool to obtain a more customized treatment. It allows the selection of those patients who will benefit most from a particular therapy and prevents the exposure of patients to toxic, noneffective regimens. Recent technical advances and the introduction of novel markers in anatomical and functional imaging have created exciting opportunities for in vivo visualization and quantification of cell death. This review will focus on in vivo apoptosis imaging as a predictive marker for tumor response after radiation. (C) 2012 by Radiation Research Society

引用

页码：467 / 482

页数：16

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