Progress in the Synthesis of Optically Pure Ethyl 2-Hydroxy-4-phenylbutyrate

被引：1
|
作者：
Zhu, Lufeng [1 ]
Chen, Houhe [1 ]
Meng, Qinghua [2 ]
Xie, Xiaomin [2 ]
Li, Yuegang [3 ]
Zhang, Zhaoguo [2 ]
机构：
[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
[3] Sinochem Int Suzhou New Mat R&D Co Ltd, Suzhou 215433, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 04期
基金：
中国国家自然科学基金;
关键词：
ethyl (R)-2-hydroxy-4-phenylbutyrate; angiotensin-converting enzyme inhibitor; asymmetric hydrogenation; enzyme; ruthenium; HIGHLY ENANTIOSELECTIVE HYDROGENATION; ALPHA-HYDROXYCARBOXYLIC ACIDS; LIPASE-CATALYZED HYDROLYSIS; DYNAMIC KINETIC RESOLUTION; CHIRAL DIPHOSPHINE LIGANDS; BIOCATALYTIC RACEMIZATION; ASYMMETRIC HYDROGENATION; MICROBIAL REDUCTION; ACTIVATED KETONES; DIASTEREOSELECTIVE SYNTHESIS;
D O I：
10.6023/cjoc1107172
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(R)-2-Hydroxy-4-phenylbutyrate is a key intermediate for the synthesis of angiotensin-converting enzyme inhibitors (ACEI). The review will cover its synthetic methods, and mainly focus on the recent progress in efficient synthesis.
引用
收藏
页码：641 / 650
页数：10
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