A Mathematical Model of Chlamydial Infection Incorporating Movement of Chlamydial Particles

被引：7
|
作者：
Mallet, Dann G. [1 ,2 ]
Bagher-Oskouei, Masoumeh [3 ]
Farr, A. Charisse [1 ]
Simpson, Daniel P. [4 ]
Sutton, Kelly-Jean [5 ,6 ]
机构：
[1] Queensland Univ Technol, Sch Math Sci, Brisbane, Qld 4001, Australia
[2] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia
[3] Med Coll Wisconsin, Biotechnol & Bioengn Ctr, Milwaukee, WI 53226 USA
[4] Norwegian Univ Sci & Technol, Dept Math Sci, N-7034 Trondheim, Norway
[5] Univ Nottingham, Sch Math Sci, Nottingham NG7 2RD, England
[6] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England
来源：
BULLETIN OF MATHEMATICAL BIOLOGY | 2013年 / 75卷 / 11期
关键词：
Chlamydia trachomatis; Partial differential equation; Infectious diseases; Treatment; DEVELOPMENTAL CYCLE; GENITAL-INFECTION; T-CELLS; TRACHOMATIS; TRACT;
D O I：
10.1007/s11538-013-9891-9
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.
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页码：2257 / 2270
页数：14
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