Design, synthesis, optimization, and biological evaluation of novel trisubstituted-benzimidazoles as efficacious antitubercular and antimicrobial agents, targeting FtsZ

被引:0
|
作者
Kumar, Kunal [1 ]
Awasthi, Divya [2 ]
Park, Bora [2 ]
Melief, Eduard [1 ]
Knudson, Susan [3 ]
Cummings, Jason [3 ]
Slayden, Richard A. [3 ]
Ojima, Iwao [1 ,2 ]
机构
[1] SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11790 USA
[2] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11790 USA
[3] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
354-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Synthesis and biological evaluation of novel antitubercular trisubstituted benzimidazoles targeting FtsZ
    Awasthi, Divya
    Kumar, Kunal
    Melief, Eduard
    Park, Bora
    Knudson, Susan
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [2] Design, synthesis, and evaluation of novel trisubstituted benzimidazoles targeting FtsZ as antimicrobial agents
    Park, Bora
    Kumar, Kunal
    Awasthi, Divya
    Melief, Eduard
    Knudson, Susan
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [3] Lead optimization of novel benzimidazoles for efficacious antitubercular agents targeting FtsZ
    Haranahalli, Krupanandan
    Kumar, Kunal
    Awasthi, Divya
    Knudson, Susan
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [4] Synthesis and evaluation of novel trisubstituted benzimidazoles targeting FtsZ as antimicrobial agents
    Park, Bora
    Kumar, Kunal
    Awasthi, Divya
    Melief, Eduard
    Cummings, Jason
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [5] Synthesis, SAR and biological evaluation of novel benzimidazoles targeting FtsZ for drug discovery of efficacious antitubercular agents
    Kumar, Kunal
    Awasthi, Divya
    Ruzsicska, Bela
    Tonge, Peter J.
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [6] Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents
    Park, Bora
    Awasthi, Divya
    Chowdhury, Soumya R.
    Melief, Eduard H.
    Kumar, Kunal
    Knudson, Susan E.
    Slayden, Richard A.
    Ojima, Iwao
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (09) : 2602 - 2612
  • [7] Synthesis and biological evaluation of novel antitubercular trisubstituted benzimidazoles and C-seco taxoids targeting FtsZ
    Awasthi, Divya
    Park, Bora
    Kumar, Kunal
    Melief, Eduard H.
    Knudson, Susan
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [8] Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents
    Kumar, Kunal
    Awasthi, Divya
    Lee, Seung-Yub
    Zanardi, Ilaria
    Ruzsicska, Bela
    Knudson, Susan
    Tonge, Peter J.
    Slayden, Richard A.
    Ojima, Iwao
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (01) : 374 - 381
  • [9] SAR study for the lead optimization of trisubstituted benzimidazoles as new-generation antitubercular agents, targeting FtsZ
    Tong, Simon
    Haranahalli, Krupanandan
    Awasthi, Divya
    Kumar, Kunal
    Knudson, Susan
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [10] Biological evaluation of novel antitubercular trisubstituted benzimidazoles on Mtb-FtsZ: Discovery of novel mechanism of action
    Awasthi, Divya
    Kumar, Kunal
    Ruzsicska, Bela
    Tonge, Peter J.
    Slayden, Richard A.
    Ojima, Iwao
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240