METHADONE-INDUCED QTC PROLONGATION IS ASSOCIATED WITH CYP2C19 GENOTYPE AND WITH PLASMA ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDENE (EDDP) CONCENTRATION: A POSSIBLE MECHANISTIC LINK

被引：0

|

作者：

Carlquist, John

Moody, David

Johnson, Eric

Jacobsen, Marian

Huntinghouse, John

Rollo, Jeffrey

Knight, Stacey

Fang, Wenfang B.

Niemann, Dawn

Morgan, Mark

Muhlestein, J.

Anderson, Jeffrey

机构：

[1] Intermt Med Ctr, Murray, UT USA

[2] Univ Utah, Salt Lake City, UT USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 63卷 / 12期

关键词：

D O I：

10.1016/S0735-1097(14)60445-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

1254-97

引用

收藏

页码：A445 / A445

页数：1

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[1] A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study
John F. Carlquist
David E. Moody
Stacey Knight
Eric G. Johnson
Wenfang B. Fang
John A. Huntinghouse
Jeffrey S. Rollo
Lynn R. Webster
Jeffrey L. Anderson
Molecular Diagnosis & Therapy, 2015, 19 : 131 - 138
[2] A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study
Carlquist, John F.
Moody, David E.
Knight, Stacey
Johnson, Eric G.
Fang, Wenfang B.
Huntinghouse, John A.
Rollo, Jeffrey S.
Webster, Lynn R.
Anderson, Jeffrey L.
MOLECULAR DIAGNOSIS & THERAPY, 2015, 19 (02) : 131 - 138
[3] QTC PROLONGATION CORRELATES WITH PLASMA ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDENE (EDDP) AMONG SUBJECTS INITIATING METHADONE MAINTENANCE THERAPY
Carlquist, John
Moody, David
Johnson, Eric
Jacobsen, Marian
Huntinghouse, John
Rollo, Jeffrey
Knight, Stacey
Fang, Wenfang
Niemann, Dawn
Morgan, Mark
Muhlestein, J.
Anderson, Jeffrey
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (10) : E1336 - E1336