Temsirolimus in patients with advanced renal cell carcinoma: an overview

被引：18
|
作者：
Bhatia, Shailender [1 ]
Thompson, John A. [1 ]
机构：
[1] Univ Washington, Div Med Oncol, Dept Med, Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
来源：
ADVANCES IN THERAPY | 2009年 / 26卷 / 01期
关键词：
kidney cancer; mTOR; rapamycin; renal cell carcinoma; targeted therapies; temsirolimus; PHASE-III TRIAL; INTERFERON-ALPHA; MAMMALIAN TARGET; PHOSPHATIDYLINOSITOL; 3-KINASE; MESSENGER-RNA; DOUBLE-BLIND; VHL GENE; RAPAMYCIN; MTOR; INHIBITOR;
D O I：
10.1007/s12325-008-0138-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Treatment of patients with advanced renal cell carcinoma (RCC) has changed dramatically with the advent of targeted therapeutics. Temsirolimus, an inhibitor of mammalian target of rapamycin (mTOR), has proven beneficial in the treatment of advanced RCC with poor prognosis. The rationale for mTOR inhibitors in treatment of RCC, the pharmacokinetics and toxicities of temsirolimus, landmark clinical trials of temsirolimus in advanced RCC, and the indications for its use in the treatment of RCC are reviewed here. The status of temsirolimus in the rapidly evolving therapeutic landscape of advanced RCC is also discussed.
引用
收藏
页码：55 / 67
页数：13
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