Resistance in Pediatric Patients Experiencing Virologic Failure With First-line and Second-line Antiretroviral Therapy

被引：16
|
作者：
Orrell, Catherine [1 ]
Levison, Julie [2 ,3 ,4 ,5 ]
Ciaranello, Andrea [2 ,3 ,4 ]
Bekker, Linda-Gail [1 ]
Kuritzkes, Daniel R. [3 ,5 ]
Freedberg, Kenneth A. [2 ,3 ,4 ,5 ,6 ,7 ]
Wood, Robin [1 ]
机构：
[1] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Desmond Tutu HIV Ctr, ZA-7925 Cape Town, South Africa
[2] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Massachusetts Gen Hosp, Med Practice Evaluat Ctr, Boston, MA 02114 USA
[5] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA
[6] Massachusetts Gen Hosp, Div Gen Med, Boston, MA 02114 USA
[7] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Boston, MA 02115 USA
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 06期
基金：
美国国家卫生研究院;
关键词：
pediatric; antiretroviral therapy; genotype; resource-limited setting; virologic failure; resistance; DRUG-RESISTANCE; CHILDREN;
D O I：
10.1097/INF.0b013e3182829092
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We examined HIV-1 resistance in children failing first-line and second-line antiretroviral therapy in South Africa, all with clade C virus. Those exposed to full-dose ritonavir had multiple protease resistance mutations. Nineteen percent had wild-type virus. Appropriate antiretroviral therapy sequencing in sub-Saharan African children is essential for prolong treatment options.
引用
收藏
页码：644 / 647
页数：4
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