Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction

被引：19

作者：

Zheng, Xiao-Hui ^{[1
,2
]}

Mu, Ge ^{[1
]}

Zhong, Yi-Fang ^{[1
]}

Zhang, Tian-Peng ^{[2
]}

Cao, Qian ^{[1
]}

Ji, Liang-Nian ^{[1
]}

Zhao, Yong ^{[2
]}

Mao, Zong-Wan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, MOE Key Lab Bioinorgan & Synthet Chem, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 98期

基金：

美国国家科学基金会;

关键词：

DNA; STABILIZATION; DISSOCIATION; SHELTERIN; BINDING; TARGET;

D O I：

10.1039/c6cc08254h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence.

引用

页码：14101 / 14104

页数：4

共 5 条

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[2] Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells
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[3] ILT4, Immunosuppression, and Resistance to Radioimmunotherapy (iRT) in Non -Small Cell Lung Cancer (NSCLC) through Recruiting SHP2 to Induce Mitochondria! Oxidative Stress-Mediated Tumor-Associated Macrophages Senescence
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[4] RETRACTED: Three novel Schiff base transition metal(II) complexes induce gastric cancer cell death through ROS-mediated apoptotic pathway (Retracted article. See DEC, 2022)
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[5] RETRACTION: Three novel Schiff base transition metal(II) complexes induce gastric cancer cell death through ROS-mediated apoptotic pathway (Retraction of Vol 72, Pg 2310, 2019)
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