Polymorphic AAAG Repeat Length in Estrogen-Related Receptor Gamma (ERRγ) and Risk of Breast Cancer in Iranian Women

被引：5

作者：

Karimi, Padideh ^{[1
]}

Hematti, Simin ^{[2
]}

Safari, Foruzan ^{[2
]}

Tavassoli, Manoochehr ^{[1
]}

机构：

[1] Univ Isfahan, Fac Sci, Dept Biol, Hezar Jarib 8174673441, Isfahan, Iran

[2] Isfahan Univ Med Sci, Dept Radiat Oncol, Esfahan, Iran

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 09期

关键词：

ERR gamma; Polymorphism; Microsatellite; Breast cancer; ORPHAN NUCLEAR RECEPTORS; DINUCLEOTIDE REPEAT; BIOMARKERS; PATHWAY; ALPHA;

D O I：

10.3109/07357907.2013.845672

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors thatmodulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG) n in the intron of ERR. gene, a case-control study of 200 breast cancer patients and 200 controls was performed in Iranian women. Our results demonstrate that women with short AAAG repeat are at higher risk of breast cancer (OR 7). This result suggests a possible involvement of polymorphic AAAG repeat of ERR. gene in regulating its expression.

引用

页码：600 / 603

页数：4

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