Masson Tumor of the Central Nervous System: A Case Report and Review of Literature

Objective: Rare diseaseBackground: Masson's tumor, also known as intravascular papillary endothelial hyperplasia (IPEH), is an unusual endothe-lial proliferation that leads to improper thrombus development due to faulty endothelial structure. Although IPEH is rare in the central nervous system, it can arise at any location in the brain. Headaches, seizures, and focal neurological symptoms ae the most common presenting symptoms. It is more common in females and it can occur at any age.Case Report: Herein, we present a 65-year-old female patient with a progressively enlarging right temporal lobe mass that was initially considered metastatic ovarian carcinoma. She underwent a right temporal craniotomy and the le-sion was totally resected. Contrary to expectations, the pathology report was an IPEH.Conclusions: In this paper, we conducted a literature review of previously reported cerebral IPEH cases, with a focus on their clinical and radiological presentations, management, and especially their association with previous radiothera-py. The important point is that one-third of the cases had a history of radiation therapy to the head, and most of them had stereotactic radiosurgery (SRS) on the location of the brain from which IPEH subsequently devel-oped. The major question for which we are looking for an answer is its relationship with previous radiothera-pies. We wanted to know how many of these cases were associated with radiotherapy in the same area, the time interval from radiotherapy to the onset of IPEH or symptoms, the dose of the previous radiotherapy, and, overall, if there is any cause-effect relationship between IPEH and radiotherapy.