Filler Materials Used in Kyphoplasty and Vertebroplasty for Osteoporotic Vertebral Compression Fractures

Osteoporosis is the most common metabolic bone disease and the most common cause of fractures in older adults. Vertebral compression fracture (VCF) is the most common complication in patients with osteoporosis. At present, vertebroplasty (VP) and kyphoplasty (KP) are two minimally invasive techniques used to treat osteoporotic vertebral compression fractures. In clinical use, KP and VP have stable and reliable therapeutic effects. However, there are still some complications and issues surrounding KP and VP application, and for long-term clinical follow-up. Thus, it is important to continue to improve the technology of the filler materials used in KP and VP in order to evolve the biomechanical characteristics of the postoperative vertebra, and to reduce the incidence of complications. The filler materials used for both techniques require good biocompatibility, good biomechanical strength and stiffness, and good radiopacity for the fluoroscopy guided procedures. PMMA and new filler materials (calcium phosphate cement, calcium sulfate cement, composite materials) are now available for clinical use. In this review paper, we will focus on the issues and characteristics of these filler materials.