MicroRNAs in Pathogenesis of Acute Kidney Injury

被引：34

作者：

Liu, Zhiwen ^{[1
]}

Wang, Shixuan ^{[2
,3
]}

Mi, Qing-Sheng ^{[4
]}

Dong, Zheng ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Dept Nephrol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China

[2] Georgia Regents Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA USA

[3] Charlie Norwood VA Med Ctr, Augusta, GA USA

[4] Henry Ford Hlth Syst, Dept Dermatol & Internal Med, Detroit, MI USA

来源：

NEPHRON | 2016年 / 134卷 / 03期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Acute kidney injury; Apoptosis; Biomarker; Cisplatin nephrotoxicity; Ischemia-reperfusion; MicroRNA; ISCHEMIA-REPERFUSION INJURY; CISPLATIN NEPHROTOXICITY; CONTRIBUTES; MIR-21; AKI; PROTECTION; MICE;

D O I：

10.1159/000446551

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression mainly by repressing their target gene translation. A large spectrum of human diseases is associated with significant changes in miRNAs. Many miRNAs are induced in diseases, whereas some others are downregulated. The significance of miRNAs has been demonstrated in renal development and physiology, and in major kidney diseases such as acute kidney injury (AKI). Recent studies have further implicated specific miRNAs in the pathogenesis of AKI. miRNAs also have the potential to become new diagnostic biomarkers of AKI. Further investigation will identify the key pathogenic miRNAs in various types of AKI and test miRNA-based therapeutics and diagnosis. (C) 2016 S. Karger AG, Basel

引用

页码：149 / 153

页数：5

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