Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation

被引：65

作者：

Liang, Qiming ^{[1
]}

Chang, Brian ^{[1
]}

Brulois, Kevin F. ^{[1
]}

Castro, Kamilah ^{[1
]}

Min, Chan-Ki ^{[1
]}

Rodgers, Mary A. ^{[1
]}

Shi, Mude ^{[1
]}

Ge, Jianning ^{[1
]}

Feng, Pinghui ^{[1
]}

Oh, Byung-Ha ^{[2
]}

Jung, Jae U. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

[2] Korea Adv Inst Sci & Technol, KAIST Inst Biocentury, Dept Biol Sci, Taejon 305701, South Korea

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

REGULATORY FACTOR 7; PROTEIN; PHOSPHORYLATION; COMPLEX; TARGETS; ATG14L; UVRAG; ORF45; LC3;

D O I：

10.1128/JVI.01898-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Autophagy is an important innate safeguard mechanism for protecting an organism against invasion by pathogens. We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.

引用

页码：12499 / 12503

页数：5

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