Function and phenotype of peptide-vaccine induced HCV-specific CD8+ T cells vs. acute and chronic hepatitis C

被引:0
|
作者
Schlaphoff, V.
Jelovcan, S. B.
Wiegand, J.
Cornberg, M.
Jilma, B.
Manns, M. P.
Wedemeyer, H.
Klade, C. S.
机构
[1] Hannover Med Sch, Dept Gastroenterol Hepatol Endocrinol, D-3000 Hannover, Germany
[2] Intercell AG, Vienna, Austria
[3] Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria
关键词
D O I
10.1016/S0168-8278(06)80445-9
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
445
引用
收藏
页码:S166 / S166
页数:1
相关论文
共 50 条
  • [1] HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients
    Feng, Guohua
    Zhang, Ji-Yuan
    Zeng, Qing-Lei
    Jin, Lei
    Fu, Junliang
    Yang, Bin
    Sun, Ying
    Jiang, Tianjun
    Xu, Xiangsheng
    Zhang, Zheng
    Yuan, Jinhong
    Wu, Liyuan
    Wang, Fu-Sheng
    MOLECULES AND CELLS, 2013, 36 (04) : 362 - 367
  • [2] Association of HCV-specific γ-interferon producing CD8+ T cells with viral clearance in acute hepatitis C
    Gruener, NH
    Gerlach, JT
    Jung, MC
    Diepolder, HM
    Zachoval, R
    Hoffmann, R
    Schraut, W
    Schirren, CA
    Santantonio, T
    Pape, GR
    HEPATOLOGY, 1998, 28 (04) : 320A - 320A
  • [3] Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+T cells in healthy individuals and chronic hepatitis C patients
    Schlaphoff, Verena
    Klade, Christoph S.
    Jilma, Bernd
    Jelovcan, Sandra B.
    Cornberg, Markus
    Tauber, Erich
    Manns, Michael P.
    Wederneyer, Heiner
    VACCINE, 2007, 25 (37-38) : 6793 - 6806
  • [4] Function is the key: impact of interferon on HCV-specific CD8+ T cells during acute HCV infection
    Bengsch, Bertram
    Thimme, Robert
    FUTURE VIROLOGY, 2008, 3 (06) : 537 - 542
  • [5] Impaired effector function of HCV-specific CD8+T cells in chronic hepatitis C virus infection
    Wedemeyer, H
    He, XS
    Nascimbeni, M
    Davis, AR
    Greenberg, HB
    Alter, H
    Rehermann, B
    JOURNAL OF HEPATOLOGY, 2001, 34 : 24 - 25
  • [6] Decline of HCV-specific CD8+ T cells during interferon-alpha therapy of acute hepatitis C (HCV): Role of apoptosis vs. differential regulation of chemokine receptors
    Wiegand, J.
    Wedemeyer, H.
    Ciner, A.
    Schlaphoff, V.
    Buggisch, P.
    Jaeckel, E.
    Manns, M. P.
    Cornberg, M.
    JOURNAL OF HEPATOLOGY, 2006, 44 : S167 - S167
  • [7] Contrasting functional characteristics of intrahepatic HCV-specific CD4+ and CD8+ T lymphocytes in mild and severe chronic hepatitis C
    Mullerova, I
    Rigopoulou, EI
    Haigh, P
    Cooksley, H
    Williams, R
    JOURNAL OF HEPATOLOGY, 2001, 34 : 25 - 25
  • [8] Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor β that can suppress HCV-specific T-cell responses
    Alatrakchi, Nadia
    Graham, Camilla S.
    van der Vliet, Hans J. J.
    Sherman, Kenneth E.
    Exley, Mark A.
    Koziel, Margaret James
    JOURNAL OF VIROLOGY, 2007, 81 (11) : 5882 - 5892
  • [9] INDIVIDUAL HIERARCHIES OF CO-STIMULATORY RECEPTORS ON HCV-SPECIFIC CD8+T-CELLS IN CHRONIC HEPATITIS C
    Schlaphoff, V.
    Jaroszewicz, J.
    Suneetha, P. V.
    Grabowski, J.
    Stegmann, K. A.
    Bakshi, R.
    Manns, M. P.
    Cornberg, M.
    Wedemeyer, H.
    JOURNAL OF HEPATOLOGY, 2010, 52 : S39 - S39
  • [10] Intrahepatic and peripheral distribution of HCV-specific CD8+ T cell responses in chronic HCV infection.
    Neumann-Haefelin, C
    Spangenberg, HC
    Panther, E
    Nazarova, N
    Kersting, N
    von Weizsaecker, F
    Blum, HE
    Thimme, R
    HEPATOLOGY, 2004, 40 (04) : 436A - 436A