The prognostic value of interim positron emission tomography scan in patients with classical Hodgkin lymphoma

被引：42

作者：

Oki, Yasuhiro ^{[1
]}

Chuang, Hubert ^{[2
]}

Chasen, Beth ^{[2
]}

Jessop, Aaron ^{[2
]}

Pan, Tinsu ^{[2
]}

Fanale, Michelle ^{[1
]}

Dabaja, Bouthaina ^{[3
]}

Fowler, Nathan ^{[1
]}

Romaguera, Jorge ^{[1
]}

Fayad, Luis ^{[1
]}

Hagemeister, Fredrick ^{[1
]}

Rodriguez, Maria Alma ^{[1
]}

Neelapu, Sattva ^{[1
]}

Samaniego, Felipe ^{[1
]}

Kwak, Larry ^{[1
]}

Younes, Anas ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Diagnost Imaging, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2014年 / 165卷 / 01期

关键词：

prognostic; positron emission tomography; Hodgkin lymphoma; INTERNATIONAL HARMONIZATION PROJECT; EVENT-FREE SURVIVAL; RESPONSE ASSESSMENT; F-18-FDG PET; CYCLES; CRITERIA;

D O I：

10.1111/bjh.12715

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognostic value of interim positron emission tomography (PET) was evaluated after 2 cycles of doxorubicin, bleomycin, vinblastin and dacarbazine in classical Hodgkin lymphoma patients (n=229), based on Deauville criteria. In early stage non-bulky disease, bulky stage II disease, advanced stage low International Prognostic Score (IPS <= 2) and advanced stage (IPS >= 3), 3-year progression-free survival rates in PET2-negative vs. PET2-positive groups were 95 center dot 9% vs. 76 center dot 9% (P<0 center dot 0018), 83 center dot 3% vs. 20 center dot 0% (P=0 center dot 017), 77 center dot 0% vs. 30 center dot 0% (P<0 center dot 001) and 71 center dot 0% vs. 44 center dot 4%(P=0 center dot 155), respectively. The outcome after positive PET2 was better than previously reported. The results from non-randomized studies of PET2-guided therapy would be valuable with careful interpretation.

引用

页码：112 / 116

页数：5

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