Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

被引：210
|
作者：
de Weerd, Nicole A. [1 ,2 ]
Vivian, Julian P. [3 ]
Nguyen, Thao K. [1 ,2 ,3 ]
Mangan, Niamh E. [1 ]
Gould, Jodee A. [1 ,2 ]
Braniff, Susie-Jane [1 ]
Zaker-Tabrizi, Leyla [1 ]
Fung, Ka Yee [1 ]
Forster, Samuel C. [1 ,2 ]
Beddoe, Travis [3 ]
Reid, Hugh H. [3 ]
Rossjohn, Jamie [2 ,3 ,4 ]
Hertzog, Paul J. [1 ,2 ]
机构：
[1] Monash Univ, Monash Inst Med Res, Ctr Innate Immun & Infect Dis, Clayton, Vic, Australia
[2] Monash Univ, Australian Res Council Ctr Excellence Struct & Fu, Clayton, Vic, Australia
[3] Monash Univ, Sch Biomed Sci, Dept Biochem & Mol Biol, Clayton, Vic, Australia
[4] Cardiff Univ, Sch Med, Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales
来源：
NATURE IMMUNOLOGY | 2013年 / 14卷 / 09期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会; 澳大利亚研究理事会;
关键词：
I INTERFERONS; ALPHA; LIPOPOLYSACCHARIDE; INDUCTION; RESPONSES; SUBUNIT; ACTIVATION; REFINEMENT; SUPPRESSOR;
D O I：
10.1038/ni.2667
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type I interferons are important in regulating immune responses to pathogens and tumors. All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet some subtypes such as interferon-beta ( IFN-beta) can exhibit distinct functional properties, although the molecular basis of this is unclear. Here we demonstrate IFN-beta can uniquely and specifically ligate to IFNAR1 in an IFNAR2-independent manner, and we provide the structural basis of the IFNAR1-IFN-beta interaction. The IFNAR1-IFN-beta complex transduced signals that modulated expression of a distinct set of genes independently of Jak-STAT pathways. Lipopolysaccharide-induced sepsis was ameliorated in Ifnar1(-/-) mice but not Ifnar2(-/-) mice, suggesting that IFNAR1-IFN-beta signaling is pathologically relevant. Thus, we provide a molecular basis for understanding specific functions of IFN-beta.
引用
收藏
页码：901 / +
页数：9
相关论文
共 50 条
  • [1] Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1
    Nicole A de Weerd
    Julian P Vivian
    Thao K Nguyen
    Niamh E Mangan
    Jodee A Gould
    Susie-Jane Braniff
    Leyla Zaker-Tabrizi
    Ka Yee Fung
    Samuel C Forster
    Travis Beddoe
    Hugh H Reid
    Jamie Rossjohn
    Paul J Hertzog
    Nature Immunology, 2013, 14 : 901 - 907
  • [2] Fine structural and functional characterization of a unique IFNβ/Ifnar1 signaling axis
    De Weerd, N.
    Nguyen, T.
    Vivian, J.
    Mangan, N. E.
    Gould, J. A.
    Noppert, S.
    Zaker-Tabrizi, L.
    Beddoe, T.
    Reid, H. H.
    Rossjohn, J.
    Hertzog, P. J.
    CYTOKINE, 2012, 59 (03) : 501 - 501
  • [3] A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling
    de Weerd, Nicole A.
    Matthews, Antony Y.
    Pattie, Phillip R.
    Bourke, Nollaig M.
    Lim, San S.
    Vivian, Julian P.
    Rossjohn, Jamie
    Hertzog, Paul J.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (18) : 7554 - 7565
  • [4] IFN-β-specific signaling via a unique IFNAR1 interaction
    Kaur, Surinder
    Platanias, Leonidas C.
    NATURE IMMUNOLOGY, 2013, 14 (09) : 884 - 885
  • [5] IFN-β-specific signaling via a unique IFNAR1 interaction
    Surinder Kaur
    Leonidas C Platanias
    Nature Immunology, 2013, 14 : 884 - 885
  • [6] Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus
    Rosenfeld, CS
    Han, CS
    Alexenko, AP
    Spencer, TE
    Roberts, RM
    BIOLOGY OF REPRODUCTION, 2002, 67 (03) : 847 - 853
  • [7] Structural basis of the differential proinflammatory signaling of type I interferons through IFNAR1 and IFNAR2 receptors
    de Weerd, Nicole A.
    Gould, Jodee A.
    Fenner, Jennifer E.
    Scott, Bernadette
    Hertzog, Paul J.
    INFLAMMATION RESEARCH, 2005, 54 : S161 - S161
  • [8] S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification
    Teijaro, John R.
    Studer, Sean
    Leaf, Nora
    Kiosses, William B.
    Nguyen, Nhan
    Matsuki, Kosuke
    Negishi, Hideo
    Taniguchi, Tadatsugu
    Oldstone, Michael B. A.
    Rosen, Hugh
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (05) : 1351 - 1356
  • [9] The expression of interferon receptor polypeptides IFNAR1 and IFNAR2 in the ovine uterus.
    Rosenfeld, CS
    Han, CS
    Roberts, RM
    BIOLOGY OF REPRODUCTION, 2001, 64 : 326 - 327
  • [10] Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2
    Piganis, Rebecca A. R.
    De Weerd, Nicole A.
    Gould, Jodee A.
    Schindler, Christian W.
    Mansell, Ashley
    Nicholson, Sandra E.
    Hertzog, Paul J.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (39) : 33811 - 33818
12345