A comparison of transcriptional activation by ERα and ERβ

被引：188
|
作者：
Cowley, SM [1 ]
Parker, MG [1 ]
机构：
[1] Imperial Canc Res Fund, Mol Endocrinol Lab, London WC2A 3PX, England
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1999年 / 69卷 / 1-6期
关键词：
D O I：
10.1016/S0960-0760(99)00055-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have compared the ability of ER alpha and ER beta to stimulate transcription from a number of reporter genes in different cell lines and demonstrate that the activity of AF1 in ER beta is negligible compared with that of ER alpha on ERE based reporters. The activity of AF2 in ER alpha and ER beta is similar and this is likely to reflect their similar ability to bind coactivators. As a consequence, when transcription from a gene depends on both AF1 and AF2 the activity of ER alpha greatly exceeds that of ER beta but when AF1 is not required ER alpha and ER beta have similar transcriptional activities. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：165 / 175
页数：11
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