Blood pressure regulation XI: overview and future research directions

被引:27
|
作者
Raven, Peter B. [1 ]
Chapleau, Mark W. [2 ,3 ,4 ]
机构
[1] Univ North Texas Hlth Sci Ctr, Dept Integrat Physiol & Anat, Ft Worth, TX 76107 USA
[2] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA
[3] Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA USA
[4] Vet Affairs Med Ctr, Iowa City, IA 52242 USA
关键词
Arterial baroreflex resetting; Cardiac output; Hemodynamic responses; Hypertension; Reactive oxygen species; Set-point theory; Operating point; Total peripheral resistance; NUCLEUS-TRACTUS-SOLITARII; NEUROGENIC HYPERTENSION; NITRIC-OXIDE; VASCULAR INFLAMMATION; OXIDATIVE STRESS; HEART-FAILURE; BRAIN-STEM; EXERCISE; BAROREFLEX; RISK;
D O I
10.1007/s00421-014-2823-z
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
While the importance of regulating arterial blood pressure within a 'normal' range is widely appreciated, the definition of 'normal' and the means by which humans and other species regulate blood pressure under various conditions remain hotly debated. The effects of diverse physiological, pathological and environmental challenges on blood pressure and the mechanisms that attempt to maintain it at an optimal level are reviewed and critically analyzed in a series of articles published in this themed issue of the European Journal of Applied Physiology. We summarize here the major points made in these reviews, with emphasis on unifying concepts of regulatory mechanisms and future directions for research.
引用
收藏
页码:579 / 586
页数:8
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