DBD dyes as fluorescent probes for sensing lipophilic environments

被引：17
|
作者：
Wawrzinek, Robert [1 ]
Wessig, Pablo [1 ]
Moellnitz, Kristian [1 ]
Nikolaus, Joerg [2 ]
Schwarzer, Roland [2 ]
Mueller, Peter [2 ]
Herrmann, Andreas [2 ]
机构：
[1] Univ Potsdam, Inst Chem, D-14476 Potsdam, Germany
[2] Humboldt Univ, Inst Biol, D-10115 Berlin, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 17期
关键词：
Fluorescence lifetime probes; FLIM; Cell staining; Lysotrackers; Detergents; CRITICAL MICELLE CONCENTRATION; SURFACTANTS; AGGREGATION; CATALYSIS; VESICLES;
D O I：
10.1016/j.bmcl.2012.07.056
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Small fluorescent organic molecules based on [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) could be used as probes for lipophillic microenvironments in aqueous solutions by indicating the critical micelles concentration of detergents and staining cell organelles. Their fluorescence lifetime decreases drastically by the amount of water in their direct environment. Therefore they are potential probes for fluorescence lifetime imaging microscopy (FLIM). (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5367 / 5371
页数：5
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