Wnt signaling in bone and muscle

被引：105

作者：

Rudnicki, Michael A. ^{[1
,2
]}

Williams, Bart O. ^{[3
]}

机构：

[1] Ottawa Hosp, Regenerat Med Program, Res Inst, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Med, Ottawa, ON, Canada

[3] Van Andel Res Inst, Ctr Skeletal Dis & Tumor Metastasis, Grand Rapids, MI USA

来源：

BONE | 2015年 / 80卷

基金：

美国国家卫生研究院;

关键词：

Wnt; Frizzled; Osteoblasts; Satellite stem cells; Muscle; Bone; PLANAR CELL POLARITY; WNT/BETA-CATENIN; BETA-CATENIN; SEROTONIN SYNTHESIS; MISSENSE MUTATIONS; MICE DEFICIENT; LRP5; MASS; PATHWAY; GENE;

D O I：

10.1016/j.bone.2015.02.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Wnt signaling plays key roles in many aspects of development. In this review, we will briefly describe the components of signaling pathways induced by Wnt ligands and then describe the current state of research as this applies to aspects of development and disease as it relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and differences in Wnt signaling in these two contexts and how these pathways are being (or could potentially be) targeted for therapeutic treatment of musculoskeletal diseases. This article is part of a Special Issue entitled "Muscle Bone Interactions". (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：60 / 66

页数：7

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