Safety and Anti-Leukemic Activity of CD123-CAR T Cells in Pediatric Patients with AML: Preliminary Results from a Phase 1 Trial

被引：21

作者：

Naik, Swati ^{[1
]}

Madden, Renee M. ^{[2
]}

Lipsitt, Amanda ^{[3
]}

Lockey, Timothy ^{[4
]}

Bran, Jennyfer ^{[3
]}

Rubnitz, Jeffrey E. ^{[5
]}

Klco, Jeffery ^{[6
]}

Shulkin, Barry ^{[7
]}

Patil, Sagar L. ^{[8
]}

Schell, Sarah ^{[8
]}

Park, Jeoungeun John ^{[3
]}

Riberdy, Janice ^{[9
]}

Shang, Na ^{[3
]}

Zoine, Jaquelyn T. ^{[8
]}

Wallace, Jennifer ^{[3
]}

Harstead, Elaine ^{[3
]}

Willis, Catherine ^{[8
]}

Metais, Jean-Yves ^{[2
]}

Langfitt, Deanna M. ^{[2
]}

Zhou, Sheng ^{[10
]}

Akel, Salem M. ^{[8
]}

Meagher, Michael M. ^{[4
]}

Triplett, Brandon M. ^{[2
]}

Gottschalk, Stephen ^{[2
]}

Velasquez, Mireya Paulina ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Bone Marrow Transplantat & Cellular Therapy, Memphis, TX USA

[2] St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Memphis, TX USA

[4] St Jude Childrens Res Hosp, Dept Therapeut Prod & Qual, 332 N Lauderdale St, Memphis, TN 38105 USA

[5] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[6] St Jude Childrens Res Hosp, Dept Hematol, 332 N Lauderdale St, Memphis, TN 38105 USA

[7] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Dept Diagnost Imaging, Memphis, TN 38163 USA

[8] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[9] St Jude Childrens Res Hosp, Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA

[10] St Jude Childrens Res Hosp, Expt Cellular Therapeut Lab, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

BLOOD | 2022年 / 140卷

关键词：

D O I：

10.1182/blood-2022-170201

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：4584 / 4585

页数：2

共 50 条

[1] Mouse CD123-CAR T Cells Elicit Robust Anti-AML Activity without HSC Toxicity in Syngeneic Models
Zoine, Jaquelyn T.
Moore, Sarah E.
Crawford, Jeremy C.
Nevitt, Chris
Langfitt, Deanna M.
Barajas, Juan M.
Abdelhamed, Sherif
Iacobucci, Ilaria
Michmerhuizen, Nicole L.
Haydar, Dalia
Krenciute, Giedre
Mullighan, Charles G.
Klco, Jeffery M.
Gottschalk, Stephen
Thomas, Paul G.
Velasquez, M. Paulina
[J]. MOLECULAR THERAPY, 2023, 31 (04) : 483 - 483
[2] Comparison of anti-leukemic activity of different effector T-cells transduced with an anti-CD33 chimeric receptor (CAR)
Marin, Virna
Pizzitola, Irene
Agostoni, Valentina
Pule, Martin
Rousseau, Raphael
Biondi, Andrea
Biagi, Ettore
[J]. HUMAN GENE THERAPY, 2009, 20 (11) : 1419 - 1419
[3] Genetic Modification of Different Effector T Cells with an Anti-CD33 Chimeric Receptor (CAR): In Vitro Evaluation and Comparison of Their Anti-Leukemic Activity
Marin, Virna
Pizzitola, Irene
Agostoni, Valentina
Pule, Martin
Rousseau, Raphael
Biondi, Andrea
Biagi, Ettore
[J]. MOLECULAR THERAPY, 2009, 17 : S218 - S218
[4] GENETIC MODIFICATION OF DIFFERENT EFFECTOR T CELLS WITH AN ANTI-CD33 CHIMERIC RECEPTOR (CAR): IN VITRO EVALUATION AND COMPARISON OF THEIR ANTI-LEUKEMIC ACTIVITY
Marin, Virna
Pizzitola, Irene
Agostoni, Valentina
Pule, Martin
Rousseau, Raphael
Biondi, Andrea
Biagi, Ettore
[J]. PEDIATRIC BLOOD & CANCER, 2009, 53 (05) : 844 - 844
[5] CAR T Cells Targeting FLT3 on AML Confer Potent Anti-Leukemic Activity and Act Synergistically with the FLT3 Inhibitor Midostaurin
Jetani, Hardikkumar
Garcia-Cadenas, Irene
Nerreter, Thomas
Rydzek, Julian
Thomas, Simone
Herr, Wolfgang
Sierra, Jordi
Bonig, Halvard
Einsele, Hermann
Hudecek, Michael
[J]. BLOOD, 2017, 130
[6] A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia
He, Simon Z.
Busfield, Samantha
Ritchie, David S.
Hertzberg, Mark S.
Durrant, Simon
Lewis, Ian D.
Marlton, Paula
McLachlan, Andrew J.
Kerridge, Ian
Bradstock, Kenneth F.
Kennedy, Glen
Boyd, Andrew W.
Yeadon, Trina M.
Lopez, Angel F.
Ramshaw, Hayley S.
Iland, Harry
Bamford, Simone
Barnden, Megan
DeWitte, Mark
Basser, Russell
Roberts, Andrew W.
[J]. LEUKEMIA & LYMPHOMA, 2015, 56 (05) : 1406 - 1415
[7] Transient responses and significant toxicities of anti-CD30 CAR T cells for CD30+lymphomas: results of a phase 1 trial
Brudno, Jennifer N.
Natrakul, Danielle A.
Karrs, Jeremiah
Patel, Nisha
Maass-Moreno, Roberto
Ahlman, Mark A.
Mikkilineni, Lekha
Mann, Jennifer
Stroncek, David F.
High, Steven L.
Fromm, Genevieve C.
Patel, Rashmika
Pittaluga, Stefania
Kochenderfer, James N.
[J]. BLOOD ADVANCES, 2024, 8 (03) : 802 - 814
[8] Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
Benjamin, Reuben
Graham, Charlotte
Yallop, Deborah
Jozwik, Agnieszka
Ciocarlie, Oana
Jain, Nitin
Jabbour, Elias J.
Maus, Marcela V.
Frigault, Matthiew
Boissel, Nicolas
Larghero, Jerome
Baruchel, Andre
Mohty, Mohamad
De Moerloose, Barbara
Bloor, Adrian
Frey, Noelle V.
Zinai, Amina
Balandraud, Svetlana
Philippe, Anne
Fouliard, Sylvain
Gauthier, Ludiane
Pauly, Jeanne
Konto, Cyril
Bermingham, Candy
Veys, Paul
Qasim, Waseem
[J]. BLOOD, 2018, 132
[9] Long-Term Anti-Leukemic Activity of Ponatinib in Patients with Philadelphia Chromosome-Positive Leukemia: Updated Results from an Ongoing Phase 1 Study
Deininger, Michael W.
Cortes, Jorge E.
Kantarjian, Hagop M.
Shah, Neil
Bixby, Dale
Mauro, Michael J.
Flinn, Ian W.
O'Hare, Thomas
Hu, Simin
Dorer, David J.
Rivera, Victor M.
Clackson, Tim
Turner, Christopher D.
Haluska, Frank G.
Druker, Brian J.
Talpaz, Moshe
[J]. BLOOD, 2012, 120 (21)
[10] Safety and early efficacy results from a phase 1, multicenter trial of PSMA-targeted armored CAR T cells in patients with advanced mCRPC.
McKean, Meredith
Carabasi, Matthew H.
Stein, Mark N.
Schweizer, Michael Thomas
Luke, Jason J.
Narayan, Vivek
Parikh, Rahul Atul
Pachynski, Russell Kent
Zhang, Jingsong
Peddareddigari, Vijay Gopal Reddy
Winnberg, James
Roberts, Amy
Rosen, Jamie
Hufner, Pam
Gladney, Whitney
Fountaine, Thomas J.
Chagin, Karen
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (06)

← 1 2 3 4 5 →