PROTAC design of Mdm2 degraders: A novel efficient approach for cancer therapy

被引：0
|
作者：
Li, Yangbing [3 ]
Yang, Jiuling [4 ]
Aguilar, Angelo [1 ,2 ]
Lu, Jianfeng [1 ,2 ]
McEachern, Donna [1 ,2 ]
Bernard, Denzil [1 ,2 ]
Wang, Shaomeng [1 ,2 ]
机构：
[1] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Internal Med, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Med Chem, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Pharmacol, Ann Arbor, MI 48109 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 254卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
323
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives
    Fang, Yuan
    Liao, Guochao
    Yu, Bin
    [J]. ACTA PHARMACEUTICA SINICA B, 2020, 10 (07) : 1253 - 1278
  • [2] PROTAC small-molecule degraders of MDM2 protein
    Aguilar, A.
    Yang, J.
    Li, Y.
    McEachern, D.
    Przybranowski, S.
    Liu, L.
    Yang, C. Y.
    Wang, S.
    [J]. EUROPEAN JOURNAL OF CANCER, 2018, 103 : E94 - E94
  • [3] Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy:advances and perspectives
    Yuan Fang
    Guochao Liao
    Bin Yu
    [J]. Acta Pharmaceutica Sinica B, 2020, 10 (07) : 1253 - 1278
  • [4] Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
    Yang, Jiuling
    Li, Yangbing
    Aguilar, Angelo
    Liu, Zhaomin
    Yang, Chao-Yie
    Wang, Shaomeng
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (21) : 9471 - 9487
  • [5] An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy
    Li, Huiwen
    Cai, Xinhui
    Yang, Xiaoyu
    Zhang, Xuan
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 272
  • [6] Inhibiting MDM2 oncogene expression as a novel approach to human cancer therapy.
    Wang, H
    Agrawal, S
    Zhang, R
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 67 (02) : 141 - 141
  • [7] MDM2 oncogene as a target for cancer therapy: An antisense approach
    Wang, H
    Zeng, XF
    Oliver, P
    Le, LP
    Chen, JD
    Chen, LH
    Zhou, WQ
    Agrawal, S
    Zhang, RW
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 1999, 15 (04) : 653 - 660
  • [8] Targeted MDM2 degradation as a novel and efficacious cancer therapy
    Yang, Jiuling
    Li, Yangbing
    Aguilar, Angelo
    McEachern, Donna
    Przybranowski, Sally
    Fernandez-Salas, Ester
    Lu, Jianfeng
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [9] MDM2 oncogene as a novel target for human cancer therapy
    Zhang, RW
    Wang, H
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2000, 6 (04) : 393 - 416
  • [10] MDM2 inhibitors for cancer therapy
    Vassilev, Lyubomir T.
    [J]. TRENDS IN MOLECULAR MEDICINE, 2007, 13 (01) : 23 - 31
12345