Kinetics of Thiazole Formation Using α-Halo Ketones and Thioamides

被引：0

作者：

Sadavarte, Prajakta Shamrao ^{[1
]}

Zaware, Bhaskar Hari ^{[1
]}

Takate, Sushama Jayawant ^{[1
]}

机构：

[1] New Arts Commerce & Sci Coll, Dept Chem, Ahmednagar, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2022年 / 38卷 / 04期

关键词：

Kinetics; Cyclisation; Thermodynamic parameter; Dielectric constant; Mechanism; POTENTIAL ANTIINFLAMMATORY AGENTS; DERIVATIVES; DESIGN; SERIES; INHIBITORS;

D O I：

10.13005/ojc/380427

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current approach involves the kinetic investigation of Thiobenzamide (TB) and cyclohexanone thiosemicarbazone (CTSC) in solution with 3-chloroacetylacetone(3-CAA). The study revealed a second-order rate constant with respect to both reactants, thioamide and an alpha-halo carbonyl compound. The energy of activation (Ea) was found to be Ea 48.8176kJ/mol/K for thiobenzamide and 33.08692157 kJ/mol/K for Cyclohexanone thiosemicarbazone. The salt effect study showed the formation of ionic species during the reaction. The reactions were studied with respect to changes in dielectric constant using solvent systems like water-ethanol and water-isopropanol.

引用

页码：1031 / 1036

页数：6

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