Hemagglutinin Receptor Specificity and Structural Analyses of Respiratory Droplet-Transmissible H5N1 Viruses

被引：55

作者：

de Vries, Robert P. ^{[1
,2
]}

Zhu, Xueyong ^{[3
]}

McBride, Ryan ^{[1
,2
]}

Rigter, Alan ^{[4
]}

Hanson, Anthony ^{[5
]}

Zhong, Gongxun ^{[5
]}

Hatta, Masato ^{[5
]}

Xu, Rui ^{[3
]}

Yu, Wenli ^{[3
]}

Kawaoka, Yoshihiro ^{[5
,6
,7
,8
]}

de Haan, Cornelis A. M. ^{[4
]}

Wilson, Ian A. ^{[3
,9
]}

Paulson, James C. ^{[1
,2
,3
]}

机构：

[1] Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA

[4] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, Utrecht, Netherlands

[5] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

[6] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Saitama, Japan

[7] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo, Japan

[8] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Special Pathogens, Tokyo, Japan

[9] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 01期

关键词：

TO-PERSON TRANSMISSION; AVIAN INFLUENZA-VIRUS; A H5N1; RECOGNITION; BINDING; GLYCANS; MAMMALS;

D O I：

10.1128/JVI.02690-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two ferret-adapted H5N1 viruses capable of respiratory droplet transmission have been reported with mutations in the hemagglutinin receptor-binding site and stalk domains. Glycan microarray analysis reveals that both viruses exhibit a strong shift toward binding to "human-type" alpha 2-6 sialosides but with notable differences in fine specificity. Crystal structure analysis further shows that the stalk mutation causes no obvious perturbation of the receptor-binding pocket, consistent with its impact on hemagglutinin stability without affecting receptor specificity.

引用

页码：768 / 773

页数：6

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