Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review

被引：46

作者：

Femminella, Grazia Daniela ^{[1
]}

Thayanandan, Tony ^{[2
]}

Calsolaro, Valeria ^{[1
]}

Komici, Klara ^{[3
]}

Rengo, Giuseppe ^{[4
,5
]}

Corbi, Graziamaria ^{[3
]}

Ferrara, Nicola ^{[4
,5
]}

机构：

[1] Imperial Coll London, Neurol Imaging Unit, London W12 0NN, England

[2] Imperial Coll London, Charing Cross Hosp, Imperial Memory Unit, London W6 8RF, England

[3] Univ Molise, Dept Med & Hlth Sci, I-86100 Campobasso, Italy

[4] Federico II Univ Naples, Dept Translat Med Sci, I-80131 Naples, Italy

[5] IRCCS, Ist Clin Sci Maugeri SPA, Soc Benefit, I-82037 Telese Terme, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期

关键词：

Alzheimer's disease; positron emission tomography (PET); magnetic resonance imaging (MRI); POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; BLOOD-BRAIN-BARRIER; PITTSBURGH COMPOUND B; PERIPHERAL BENZODIAZEPINE-RECEPTOR; CEREBRAL GLUCOSE-METABOLISM; PARTIAL VOLUME CORRECTION; BETA-AMYLOID BURDEN; FLORBETAPIR F 18; IN-VIVO;

D O I：

10.3390/ijms19123702

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer's, as they provide an in vivo window to the pathological processes occurring in Alzheimer's brain. While some imaging techniques are still under evaluation in the research setting, some have reached widespread clinical use. In this review, we provide an overview of the most commonly used imaging biomarkers in Alzheimer's disease, from molecular PET imaging to structural MRI, emphasising the concept that multimodal imaging would likely prove to be the optimal tool in the future of Alzheimer's research and clinical practice.

引用

页数：23

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