Effect of dietary vitamin D3 on T helper-related activities of lupus-prompt New Zealand black/New Zealand white F1 mice

被引：0

作者：

Yang, BC ^{[1
]}

Liu, CW ^{[1
]}

Yu, CK ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70428, Taiwan

来源：

JOURNAL OF FOOD AND DRUG ANALYSIS | 1999年 / 7卷 / 03期

关键词：

vitamin D-3; cytokines; lupus;

D O I：

暂无

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We investigated the effect of dietary vitamin D-3 on T helper-related activities and progress of lupus in NZB/NZW F1 mice. Mice were fed with 0.4 or 2 mu g vitamin D-3 dissolved in 50 mu L olive oil every other day. Expression of T cell-related cytokine genes including those of IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 and IPN-gamma was monitored during the disease course by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). In addition, total serum IgG1 and IgG2a and anti-dsDNA antibody were measured. We observed a prolonged survival of mice receiving 2 mu g of vitamin D-3 as compared With control mice. However, vitamin D-3 did not significantly affect the anti-DNA antibody formation, IgG subtype proportion, or cytokine expression profile.

引用

页码：169 / 175

页数：7

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