Synthesis and pharmacological evaluation of irreversible allosteric ligands for the M1 muscarinic acetylcholine receptor

被引:0
|
作者
Davie, B. J. [1 ]
Valant, C. [1 ]
Capuano, B. [2 ]
Scammells, P. J. [2 ]
Christopoulos, A. [1 ]
机构
[1] Monash Inst Pharmaceut Sci, Drug Discovery Biol, Melbourne, Vic, Australia
[2] Monash Inst Pharmaceut Sci, Med Chem, Melbourne, Vic, Australia
关键词
D O I
10.1016/S0924-977X(13)70449-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
P.1.j.011
引用
收藏
页码:S287 / S288
页数:2
相关论文
共 50 条
  • [1] Regulation of the M1 muscarinic acetylcholine receptor by orthosteric and allosteric ligands
    Thomas, R.
    Langmead, C.
    Wood, M.
    Challiss, J.
    [J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 : 28 - 28
  • [2] Differential Regulation of the M1 Muscarinic Acetylcholine Receptor by Orthosteric and Allosteric Ligands
    Thomas, Rachel
    Langmead, Christopher
    Wood, Martyn
    Challiss, John
    [J]. FASEB JOURNAL, 2008, 22
  • [3] Identification of multiple allosteric sites on the M1 muscarinic acetylcholine receptor
    Espinoza-Fonseca, LM
    Trujillo-Ferrara, JG
    [J]. FEBS LETTERS, 2005, 579 (30) : 6726 - 6732
  • [4] Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor
    Abdul-Ridha, Alaa
    Lopez, Laura
    Keov, Peter
    Thal, David M.
    Mistry, Shailesh N.
    Sexton, Patrick M.
    Lane, J. Robert
    Canals, Meritxell
    Christopoulos, Arthur
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (09) : 6067 - 6079
  • [5] Development of a Photoactivatable Allosteric Ligand for the M1 Muscarinic Acetylcholine Receptor
    Davie, Briana J.
    Sexton, Patrick M.
    Capuano, Ben
    Christopoulos, Arthur
    Scammells, Peter J.
    [J]. ACS CHEMICAL NEUROSCIENCE, 2014, 5 (10): : 902 - 907
  • [6] Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor
    Jakubík, J
    Tucek, S
    El-Fakahany, EE
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 301 (03): : 1033 - 1041
  • [7] Synthesis and Pharmacological Evaluation of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) Designed to Bind Irreversibly to an Allosteric Site of the M1 Muscarinic Acetylcholine Receptor
    Davie, Briana J.
    Valant, Celine
    White, Jonathan M.
    Sexton, Patrick M.
    Capuano, Ben
    Christopoulos, Arthur
    Scammells, Peter J.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (12) : 5405 - 5418
  • [8] Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles
    Dallagnol, Juliana C. C.
    Khajehali, Elham
    van der Westhuizen, Emma T.
    Jorg, Manuela
    Valant, Celine
    Goncalves, Alan G.
    Capuano, Ben
    Christopoulos, Arthur
    Scammells, Peter J.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (07) : 2875 - 2894
  • [9] Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
    Ma, Lei
    Seager, Matthew
    Wittmann, Marion
    Jacobson, Marlene
    Bickel, Denise
    Burno, Maryann
    Jones, Keith
    Graufelds, Valerie Kuzmick
    Xu, Guangping
    Pearson, Michelle
    McCampbell, Alexander
    Gaspar, Renee
    Shughrue, Paul
    Danziger, Andrew
    Regan, Christopher
    Flick, Rose
    Pascarella, Danette
    Garson, Susan
    Doran, Scott
    Kreatsoulas, Constantine
    Veng, Lone
    Lindsley, Craig W.
    Shipe, William
    Kuduk, Scott
    Sur, Cyrille
    Kinney, Gene
    Seabrook, Guy R.
    Ray, William J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (37) : 15950 - 15955
  • [10] Allosteric Modulation of M1 Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking
    Yeatman, Holly R.
    Lane, J. Robert
    Choy, Kwok Ho Christopher
    Lambert, Nevin A.
    Sexton, Patrick M.
    Christopoulos, Arthur
    Canals, Meritxell
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (22) : 15856 - 15866