Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sjogren's syndrome

被引：7

作者：

Smolenska, Zaneta ^{[2
]}

Pawlowska, Justyna ^{[1
]}

Zdrojewski, Zbigniew ^{[2
]}

Daca, Agnieszka ^{[1
]}

Bryl, Ewa ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Pathophysiol, PL-88210 Gdansk, Poland

[2] Med Univ Gdansk, Dept Internal Med Connect Tissue Dis & Geriatr, PL-88210 Gdansk, Poland

来源：

CELLULAR IMMUNOLOGY | 2012年 / 278卷 / 1-2期

关键词：

Sicca syndrome; Primary Sjogren's syndrome; T cell subpopulations; CD28; molecule; Costimulation signal; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; CLASSIFICATION CRITERIA; MULTIPLE-SCLEROSIS; IMMUNE-SYSTEM; CD28; CD8(+)CD28(-); AUTOIMMUNITY; LYMPHOCYTES; EXPRESSION;

D O I：

10.1016/j.cellimm.2012.08.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of CD28- T cell subpopulations in primary Sjogren's syndrome (pSS) has become controversial. Changes in the number of CD28- T cells have been demonstrated in autoimmune diseases in co-existence with Sjogren's syndrome. The study aimed to indicate differences in the number of CD4+CD28- and CD8+CD28- T cells in patients with sicca syndrome and suspected pSS. Thirty patients with sicca syndrome at baseline were studied and followed up for 5 months. After final diagnosis, comparison was made of the previously recorded lymphocyte subpopulations in patients with pSS and those in other defined subgroups. Notably high percentages of CD8+CD28- T cells were indicated in pSS patients, which correlated with the severity of the sicca symptoms and cutaneous and muscular systemic disease activity. Changes in CD8+CD28- T cell percentages may thus assist in the early differential diagnosis of pSS patients from those with similar clinical symptoms. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：143 / 151

页数：9

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