Invasive Haemophilus influenzae Serotype e and f Disease, England and Wales

被引:55
|
作者
Ladhani, Shamez N. [1 ,2 ]
Collins, Sarah [1 ]
Vickers, Anna [1 ]
Litt, David J. [1 ]
Crawford, Carina [1 ]
Ramsay, Mary E. [1 ]
Slack, Mary P. E. [1 ]
机构
[1] Hlth Protect Agcy, London, England
[2] St Georges Univ London, London, England
关键词
CHANGING EPIDEMIOLOGY; B HIB; INFECTIONS; VACCINE; POPULATION; CHILDREN; REPLACEMENT; IMPACT; CANADA; ADULTS;
D O I
10.3201/eid1805.111738
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Haemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hit, is increasing; during 2001-2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009-2010, Hit incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rate within 7 clays of diagnosis was higher for Hie, even after adjustment for age and comorbidities. Multi locus sequence typing revealed a single major circulating clone for both Hit (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found.
引用
收藏
页码:725 / 732
页数:8
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