Filling the gap: Chemistry of 3,5-bis(trifluoromethyl)-1H-pyrazoles

被引：29
|
作者：
Maspero, Angelo [1 ]
Giovenzana, Giovanni B. [2 ]
Monticelli, Damiano [1 ]
Tagliapietra, Silvia [3 ]
Palmisano, Giovanni [1 ]
Penoni, Andrea [1 ]
机构：
[1] Univ Insubria, Dipartimento Sci & Alta Tecnol, I-22100 Como, Italy
[2] Univ Piemonte Orientale, Dipartimento Sci Farmaco, I-28100 Novara, Italy
[3] Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 139卷
关键词：
Pyrazoles; Electrophilic aromatic substitution; Heterocycles; METAL-ORGANIC FRAMEWORKS; HYDROGEN STORAGE; ACID; TRIFLUOROMETHYL; BROMINATION; POTASSIUM; AROMATICS; FLUORINE; SODIUM;
D O I：
10.1016/j.jfluchem.2012.04.003
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Pyrazoles represent important building blocks for the preparation of bioactive compounds and a large variety of materials, due to their rich coordination chemistry. Unusual and interesting properties may be imparted to molecules embodying highly fluorinated pyrazoles, but to date only few examples of polyfluorinated pyrazoles have been described. In this work we report an improved preparation of 3,5-bis(trifluoromethyl)-1H-pyrazole, the subsequent transformation into hitherto unknown 4-functionalized (F, Cl, Br, I, NO2, NH2) derivatives and the evaluation of selected chemical and physical properties of these compounds. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：53 / 57
页数：5
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