Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobactetium tuberculosis isolates

被引：70
|
作者：
Plinke, C [1 ]
Rüsch-Gerdes, S [1 ]
Niemann, S [1 ]
机构：
[1] Forschungszentrum Borstel, Natl Reference Ctr Mycobacteria, D-23845 Borstel, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 05期
关键词：
D O I：
10.1128/AAC.50.5.1900-1902.2006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB] -resistant strains, 33 multidrugresistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.
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页码：1900 / 1902
页数：3
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