Association of thePSRC1rs599839 Variant with Coronary Artery Disease in a Mexican Population

Background and Objectives:Coronary artery disease (CAD) is a major health problem in Mexico. The identification of modifiable risk factors and genetic biomarkers is crucial for an integrative and personalized CAD risk evaluation. In this work, we aimed to validate in a Mexican population a set of eight selected polymorphisms previously associated with CAD, myocardial infarction (MI), or dyslipidemia.Materials and Methods: A sample of 907 subjects (394 CAD cases and 513 controls) 40-80 years old was genotyped for eight loci:PSRC1(rs599839),MRAS(rs9818870),BTN2A1(rs6929846),MTHFD1L(rs6922269),CDKN2B(rs1333049),KIAA1462(rs3739998),CXCL12(rs501120), andHNF1A(rs2259816). The association between single nucleotide polymorphisms (SNPs) and CAD was evaluated by logistic regression models.Results:Multiple logistic regression analysis with adjustment by age, gender, and body mass index showed that rs599839 was significantly associated with CAD (ORADD= 0.72,p= 0.009; ORDOM= 0.66,p= 0.007).Conclusions:ThePSRC1rs599839 polymorphism shows a significant protective association with CAD in this sample of the Mexican population.