Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

被引:88
|
作者
Joseph, Andrew W. [2 ]
D'Souza, Gypsyamber [1 ]
机构
[1] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA
关键词
Human papillomavirus; HPV; Head and neck cancer; Oropharyngeal cancer; Squamous cell carcinoma; Epidemiology; SQUAMOUS-CELL CARCINOMA; EPSTEIN-BARR-VIRUS; ORAL HUMAN-PAPILLOMAVIRUS; POLYMERASE-CHAIN-REACTION; RISK HUMAN-PAPILLOMAVIRUS; RECURRENT RESPIRATORY PAPILLOMATOSIS; HPV-INFECTION; OROPHARYNGEAL CANCER; NASOPHARYNGEAL CARCINOMA; LARYNGEAL CARCINOMA;
D O I
10.1016/j.otc.2012.04.003
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.
引用
收藏
页码:739 / +
页数:27
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