Purpose: Adolescents with pediatric onset multiple sclerosis (MS) engage in low rates of physical activity. Behavioral interventions that target physical activity are most successful if grounded in theory. This study explored social cognitive theory (SCT) variables as correlates of physical activity among adolescents with pediatric onset MS. Procedures: Participants who had a diagnosis of pediatric onset MS, were between the ages of 14 and 18 years, and were fluent and literate in English were eligible. The electronic web -delivered survey included a demographics questionnaire, the Godin Leisure Time Exercise Questionnaire (GLTEQ), and measures of SCT vari- ables. Results: The overall sample included 24 adolescents with pediatric onset MS (M:3,F:21) with a mean age of 16.1 years and disease duration of 2.6 years. The sample was predominately Caucasian (n = 14, 58%). Exercise planning (rho=0.54), exercise outcome expectations (rho=0.46), self -efficacy for overcoming barriers (rho = 0.52), and exercise social support (rho=0.58) were associated with GLTEQ scores. Conclusions: Researchers might develop behavioral interventions that target exercise outcome expectations, exercise planning, self -efficacy for overcoming barriers, and exercise social support for changing physical activity in pediatric onset MS.