Digital rock physics technology makes up for the disadvantages of traditional petrophysical experiments, and has opened up a new platform for petrophysics research. Taking sandstone as study object, this paper introduces a systematic process of digital rock physics: based on micro-CT scanning and advanced image processing technology we build a three-dimensional digital core model with real pore structure characteristics; with the application of Avizo software which contains a variety of morphological algorithm, the research of quantification and characterization of the pore structure is conducted, the porosity, pore volume distribution and pore size distribution characteristics are obtained by statistical methods, and the equivalent pore network model is built; the Avizo and Comsol multiphysics softwares are interactively combined in this paper, which realize the pore-scale flow simulation as well as the absolute permeability calculation; for the case of the solid phase pore-filling, the effective elastic parameter of the rock is simulated, the result has a good validation with the approximate Gassmann equation. Our study enriches the existing research approaches of digital rock physics, simultaneously opens up a new pathway for its wide-scale development.