Monanchomycalin C, a New Pentacyclic Guanidine Alkaloid from the Far-Eastern Marine Sponge Monanchora pulchra

被引：0

作者：

Tabakmakher, Ksenya M. ^{[1
]}

Denisenko, Vladimir A. ^{[1
]}

Guzii, Alla G. ^{[1
]}

Dmitrenok, Pavel S. ^{[1
]}

Dyshlovoy, Sergey A. ^{[1
]}

Lee, Hyi-Seung ^{[2
]}

Makarieva, Tatyana N. ^{[1
]}

机构：

[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far East Branch, Vladivostok 22, Russia

[2] Korea Inst Ocean Sci Technol, Marine Nat Prod Lab, Ansan 426744, South Korea

来源：

NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 10期

关键词：

Pentacyclic guanidine alkaloids; Monanchomycalin; Marine sponge; Monanchora pulchra; NMR; Cytotoxic activity; PTILOMYCALIN-A; CRAMBE-CRAMBE; CRAMBESCIDIN-800; CHEMISTRY; ARBUSCULA; BIOLOGY; HIV-1;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and mass spectrometric data. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 mu M and 4.3 mu M, respectively.

引用

页码：1399 / 1402

页数：4

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