Total Synthesis of (+)-Gregatin B and E

被引：24

作者：

Kusakabe, Taichi ^{[1
]}

Kawai, Yasuko ^{[1
]}

Kato, Keisuke ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 19期

关键词：

PD(II)-MEDIATED CYCLIZATION-CARBONYLATION; COUPLING REACTIONS; IODIDES; ASPERTETRONIN; DERIVATIVES; GREGATINS; REVISIONS; GRAMININ; ALKYNES; ACCESS;

D O I：

10.1021/ol402472q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of (+)-gregatin E and a new total synthesis of (+)-gregatin B are described. Key features of our synthetic approach involve a palladium-catalyzed cyclization-methoxycarbonylation of optically active propargylic acetate and a Suzuki-Miyaura coupling or CuTC-mediated coupling reaction. The absolute configuration of (+)-gregatin E (5R,5'S) is proposed.

引用

页码：5102 / 5105

页数：4

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