Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

被引：9

作者：

Yu, Kenny ^{[1
]}

Roncaroli, Federico ^{[2
]}

Kearney, Tara ^{[3
]}

Ewins, David ^{[4
]}

Beeharry, Deepa ^{[4
]}

Naylor, Thomas ^{[4
]}

Ray, David ^{[3
]}

Bhalla, Rajiv ^{[5
]}

Gnanalingham, Kanna ^{[1
]}

机构：

[1] Salford Royal NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Dept Neurosurg, Salford M6 8HD, Lancs, England

[2] Univ Manchester, Sch Biol Sci, Div Neurosci & Expt Psychol, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England

[3] Salford Royal NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Dept Endocrinol, Salford M6 8HD, Lancs, England

[4] Countess Chester Hosp, Dept Endocrinol, Liverpool Rd, Chester CH2 1UL, Cheshire, England

[5] Salford Royal NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Dept Otorhinolaryngol, Salford M6 8HD, Lancs, England

来源：

ACTA NEUROCHIRURGICA | 2018年 / 160卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Olfactory neuroblastoma; Ectopic; ACTH; Cushing's; ADRENOCORTICOTROPIC HORMONE; EXPERIENCE;

D O I：

10.1007/s00701-017-3447-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present the case of a patient with Cushing's syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient's cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.

引用

页码：1023 / 1026

页数：4

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